Endocrine Abstracts

Historically, the 131I whole body scan played a central role in the assessment of disease status in patients with differentiated thyroid cancer.In 2006, the European Thyroid Cancer Taskforce published a new Consensus Statement. It favoured the use of stimulated serum thyroglobulin measurement and neck ultrasound for follow up of disease activity. The use of diagnostic 131I whole body scan was no longer recommended as a routine test....

FPLD is a rare monogenic cause of insulin resistance. We document responses to treatment with metformin in 2 adolescent sisters with FPLD due to heterozygosity for R482W LMNA gene mutation.The probands, aged 14 and 16 years, presented with secondary amenorrhoea, hirsutism and progressive acanthosis nigricans. Phenotypically they showed central obesity, nuchal enlargement, and thin muscular arms. These changes occurred post-pubertally. Anthrpometri...